Consent
Settings
Cookie information
Cookie information

We use cookies to customize content and ads and to analyze access to our website. In addition, we share information about your use of our website with our analytics partners. Our partners may combine this information with other data that you have provided to them or that they have collected in the course of your use of their services.

Cookie settings
  • Essential 3

    Essential cookies help make a website user-friendly by enabling basic functions such as page navigation and access to secure areas of the website. Without these cookies, the website cannot function properly.

    Cookie declaration
    Name Provider Purpose Expiration date
    accepted_cookies kinaselogistics.com Stores the status of the visitor's consent for cookies of the current domain. 1 year
    accepted_cookie_types kinaselogistics.com Stores the type of cookies that the visitor has agreed to for the current domain. 1 year
    __cf_bm myfonts.net This website uses a web font from myfonts.com or hello.myfonts.net. The cookie is used to comply with the licensing terms for the use of this font style. In doing so, visits to the website are recorded for statistical purposes and transmitted to Monotype Imaging Holdings Inc, 600 Unicorn Park Drive, Woburn, MA 01801, USA. 1 year
  • stats 3

    Statistical cookies help website owners understand user behavior on their websites by collecting and reporting anonymous information. This allows them to understand how visitors interact with the web pages.

    Cookie declaration
    Name Provider Purpose Expiration date
    MATOMO_SESSID matomo.org This cookie is placed by the statistics/analysis tool Matomo (formerly Piwik). It provides the function to disable or enable Matomo. If the user chooses to disable or enable, other cookies (mtm_consent, mtm_consent_removed, mtm_cookie_consent or piwik_ignore) are set by Matomo to store whether tracking should occur. 14 days
    _pk_id.1.2494 matomo.org This cookie is placed by the statistics/analysis tool Matomo (formerly Piwik). It is used to store some details about the user, such as the unique visitor ID. 13 months
    _pk_ses.1.2494 matomo.org This cookie is placed by the statistics/analysis tool Matomo (formerly Piwik). It is used to store some details about the user, such as the unique visitor ID. 30 minutes
About cookies on this website

Cookies are small text files used by websites to make the user experience more efficient.

In accordance with applicable law, we store necessary cookies on your device, as they are essential for the operation of this site. For all other cookie types, we need your consent. Necessary cookies are processed pursuant to Article 6(1)(f) DSGVO, while other cookies, such as preference and marketing cookies, are processed on the basis of Article 6(1)(a) DSGVO.

This website uses various types of cookies, including those from third-party providers.

You can change or revoke your consent at any time in the cookie declaration on our website.

For more information about our identity, contact details and processing of personal data, please see our Privacy Policy.

Confirm selection
Confirm all

Services
Activity-based Biochemical Screening/Profiling Assay Services

Once compounds are identified, Mechanism of Action studies are necessary to characterize and compare the potential drug candidates. In cooperation with Carna Biosciences, we offer activity-based kinase profiling and screening services for assessing the potency and selectivity of your compounds. We offer to test at higher ATP concentration (1mM) to provide insight into compound inhibition and potency under more physiologically relevant conditions, in addition to our ~ATP km assay services.

Features of our profiling and screening assays:

  • Massive Kinome Coverage
  • Activity-Based Profiling & Screening
  • Confirm your results at higher ATP concentrations to identify potential Type II/III inhibitors
  • Build your own panel or consider our unique pre-selected panels.

Mobility Shift Assay(MSA)/IMAP™ Kinase Assay Services

Mobility Shift Assays/IMAP™ assays directly monitor phosphorylation by measuring the non-phosphorylated and phosphorylated substrate in the kinase reaction. The technology is based on microfluidics on a microchip involving the electrophoretic separation and quantification of the fluorescently labeled substrate and the phosphorylated product. The potency and selectivity of your compounds are assessed against the target kinases you select. All kinases utilized in our assays are produced and guaranteed to be of the highest quality, enabling us to deliver high-quality data to you. The ATP concentration in our assays is set around the Km value. For an enhanced understanding of selectivity and allosterism, many assays have also been validated using 1mM ATP. For slow-binding compounds, we offer assays pre-incubating the kinase with your compounds. 

See all available Targets

Links & Downloads

Kinase Screening Kinase Profiling

ADP-Glo™ Kinase Assay for Lipid Kinase Screening & Profiling

For Lipid kinase screening and profiling we use the ADP-Glo™ assay platform.  The potency and selectivity of your compounds is measured via ADP formed from a kinase reaction. The ADP is converted into ATP, which is used to generate light in a luciferase reaction. The luminescence (RLU value) generated correlates with kinase activity. The ATP concentration of our lipid kinase assays is set at the approximate Km for each kinase.

See all available Targets

Links & Downloads

Scientist typing on Laptop

Newsletter

Newsletter abonnieren Icon
Contact us